In this article we will dive all into

• What Is DADA?
• How Does DADA Work In the Body
• Benefits of DADA
• Side Effects of DADA
• My Experience with DADA
• DADA Dosing
• Scientific Data On DADA

And More!

IF YOU ARE LOOKING FOR ORAL DADA IT CAN BE FOUND HERE CODE: BIOHACK

IF YOU ARE LOOKING FOR Injectable DADA IT CAN BE FOUND HERE CODE BIOHACK

What Is DADA?

Diisopropylamine dichloroacetate (DADA) is a derivative of dichloroacetate (DCA), a compound studied for its impact on cellular energy metabolism and potential therapeutic effects. DADA works by targeting mitochondrial function, particularly influencing pyruvate dehydrogenase kinase (PDK) inhibition. By inhibiting PDK, DADA promotes the activity of pyruvate dehydrogenase (PDH), which plays a crucial role in glucose metabolism and the production of cellular energy. This pathway enhances the shift from anaerobic glycolysis (often associated with conditions like cancer and metabolic disorders) to aerobic respiration, supporting a healthier metabolic state and energy production efficiency.

How Does DADA Work In the Body

DADA’s primary mechanism is through PDK inhibition, which boosts PDH activity. This activity shift can help cells more effectively utilize glucose in the mitochondria, thereby producing ATP with less lactate buildup. This mechanism has made DADA, like DCA, a point of interest in studying diseases associated with mitochondrial dysfunction or altered cellular metabolism.

Essentially it removes the rate limiting step in the energy production process. In the same way that Yk-11 lowers myostatin allowing you to build more muscle, DADA does a similar thing (of course not via myostatin) when it comes to endurance.

Benefits of DADA

Now DADA has alot of benefits that it can be very useful for. I will try to run through them in a pretty quick and straightforward manner.

1. Improved Endurance and Workout Performance: Really if you are an athlete of any kind DADA can be amazing for helping to improve your muscular endurance.
2. Improved Mitochondrial Function: DADA also seems to help improve how well the mitochondria functions which leads to better energy
3. Potential Treatment for Metabolic Disorders
4. Potential Treatment for Heart Failure (may be cardioprotective)
5. Synergistic with Melatonin (has bene shown in mouse MS models to Ameliorate Melatonin Therapy) I have noticed it seems to be able to reduce some of the Melatonin side effects like grogginess in the morning.
6. PDK signaling has also been thought of as a potential cancer therapy
7. Helps to alleviate liver fibrosis

DADA Side Effects

DADA has a pretty minimal side effect profile. Some people do get Peripheral Neuropathy, GI stress, and in some cases mild fatigue (most people though do get more energy)

The other major side effect to discuss is that for high level athletes DADA has the potential to lead them to overtrain due to the increase in exercise performance so you can raise your injury risk.

My Experience with DADA

For me DADA behaved as part

DADA Dosing

When using DADA as an injectable I notice the best results when it is pinned consistently. For me I was using around 200mg per day. 100mg in the morning pre fasted cardio and then another 100mg before bed with my melatonin. Typically you can go higher then this and I have seen high level athletes dose it higher. Try to use it as consistently as possible to really reap the best results from it. I have seen guys take it up to 300mg and up but again these are high level athletes. For general pop guys between 100-200mg is a perfect dose. For me it takes around 30-45 minutes for it to kick in. I will note that DADA can also be used orally and I find it very effective when used orally! The injectable is slightly more effective, but the oral has also worked very well for me.

Beginner Dosing: 100mg and below

Intermediate Dosing: 150-200mg

High Level Athlete Dosing: 300mg+

 

Some of my favorite things to use with DADA are as follows

• L-Carnitine
• Injectable Choline
• Cardarine
• ATP
• Creatine
• AMP
• ITPP
• Melatonin
• SLU-PP-332

Scientific Studies with DADA

Here are a few great resources to look over with DADA

DADA and Liver Fibrosis

DADA in Organ Failure and Metabolic Disorders

DADA Anti Tumor Effect on Non Small Cell Lung Cancer

DADA and Nonalcoholic Fatty Liver Disease