Baseline (Prevention)

Nootropics include:

• Racetams (piracetam, phenylpiracetam)

• Cholinergics (citicoline, alpha-GPC)

• Ampakines

• Adaptogens (rhodiola, ashwagandha)

To avoid receptor fatigue:

• Rotate compounds weekly

• Avoid chronic high doses of any single agent

• Always stack with a choline source when using racetams

Active Tachyphylaxis

If cognitive benefits begin to fade:

• Discontinue all racetams and cholinergics for two weeks

• Receptor desensitization (especially AMPA and nicotinic) may be active

• During this break, use only:

  • Adaptogens

  • Magnesium threonate

  • Antioxidants (e.g., ALCAR, NAC)

Withdrawal Transition

• Support recalibration with:

  • B-vitamins

  • Citrulline (for nitric oxide and cerebral perfusion)

  • Uridine

• Prioritize:

  • Sleep

  • Glymphatic flow

• Avoid:

  • Caffeine

  • Synthetic stimulants
    to allow dopamine and acetylcholine pathways to normalize

Neurorestoration Phase

• Promote neuroplasticity with:

  • Lion’s mane

  • 7,8-DHF

  • Omega-3s

  • Uridine

  • Aerobic training

• Consider microstacking:

  • 1/10th standard dose of piracetam + choline source

• Focus on complex skill learning and memory formation

Maintenance / Reinforcement

• Reintroduce nootropics on cyclical schedules:

  • Racetams: max 3 days/week

  • Ampakines: burst use only

  • Rotate adaptogens every 2 weeks

• Track performance by monitoring:

  • Baseline cognition

  • Pulse

  • Heart Rate Variability (HRV)