Semaglutide is one of the earlier GLP-1 receptor agonists, and while effective, it can cause low energy and gastrointestinal (GI) issues. Here’s how I would personally use it to mitigate these effects and enhance overall results:

1. Dosing Strategy

• Start with three small doses per week of 100mcg.
• Gradually increase the dosage over time until you reach a total weekly dose of 1-2mg.

2. Supporting Gut Health

• Implement BPC-157 to help protect and heal the gut while using Semaglutide.

3. Combating Low Energy

• MOTS-C: Inject 5mg, three times per week to support mitochondrial function and energy production.
• 5-Amino-1MQ: Inject 5mg, three times per week to counteract any metabolic slowdowns.

4. Enhancing Cardio Performance & Energy

• Methylene Blue: Take 5mg to help boost mitochondrial efficiency and cardiovascular performance.

5. Boosting Fat Loss

• Carnitine (600mg) + AOD-9604 (300mcg)
• Taken twice daily, fasted to support lipolysis and beta-oxidation of fat cells.

By following this stacked approach, you can minimize common side effects of Semaglutide while maximizing energy, gut health, and fat loss efficiency.