Baseline (Prevention)

Classical psychedelics include tryptamines (psilocin, DMT), phenethylamines (mescaline, 2C-x), and ergot derivatives (LSD, LSA). All act primarily via 5-HT2A agonism.

• Allow at least 10–14 days between sessions to prevent tolerance

• Avoid redosing or stacking within a single trip

• Do not combine with MAOIs unless intentional and carefully controlled

Active Tachyphylaxis

When tolerance develops:

• 5-HT2A downregulation and receptor desensitization are in effect

• Cease use for a minimum of two weeks

• Support serotonin homeostasis with:

  • Tryptophan

  • 5-HTP (used cautiously)

  • Vitamin B6

• Avoid stimulants and empathogens that deplete serotonin

• Add magnesium and zinc to stabilize receptor coupling

Withdrawal Transition

• Manage serotonin depletion symptoms with:

  • Tyrosine (buffers dopamine drop)

  • Rhodiola

  • Adaptogens

• Use L-theanine for mood regulation

• Microdose 7,8-DHF and citicoline to support receptor sensitivity recovery

• Restore circadian rhythm and glymphatic function through prioritizing deep sleep

Neurorestoration Phase

• Promote neuroplasticity with:

  • Lion’s mane

  • Aerobic exercise

  • Intermittent fasting

• Add:

  • Uridine

  • Omega-3s

  • Creatine

• Avoid nootropics that overstimulate 5-HT receptors

• Reset the default mode network with meditation or float tanks to recalibrate introspective circuits

Maintenance / Reinforcement

• Space trips at a minimum of three weeks apart

• Microdosing (psilocybin or LSD) should follow one-day-on, two-days-off models

• Maintain serotonin precursors and antioxidant support:

  • Vitamin C

  • NAC

  • ALCAR

• Avoid tolerance stacking with MDMA or DOx compounds