In this article we will go over the following GLP-1s and I will provide you with a quick breakdown on how they can be deployed and key differences!

Here are the GLP-1s that will be covered. The goal with this is of course to give people an easy way to breakdown the differences in each one and the unique benefits that each one comes with, and the potential side effects.

• Semaglutide
• Oral AQA Semaglutide
• Tirzepaptide
• Retatrutide
• Mazdutide
• Cagrisema
• Cagrilintide
• Survodutide

Intro

Hello friends before reading I want you guys to be aware of a few things. #1 most of these have similar side effect profiles. When you are dealing with GLP-1s the biggest thing is going to be the GI stress and the GI based side effects.  Low energy is also an issue for most that do not agonize the glucagon receptor. I have noticed that when this glucagon receptor is activated this issue is much less pronounced. My personal favorite GLP-1 is retatrutide, because it is the most effective with the last amount of side effects. Also it is worth noting that across all of them most will do things like bring down HBA1C levels, improve inflammation, lower blood pressure, etc as usually alot of these benefits come from losing weight and getting healthy. So if you see that I did not repeat for everyone lowered HBA1C as a benefit just know that it likely does that.

Oral AQA Semaglutide Drops

Before I start discussing these I want to clarify that these are a prescription product! If you are interested in trying these out you can head over to https://www.nutelemed.com/nanodrops-rx/ and get started with the free 10 minute assessment to see if you are a candidate or not. This assessment will be reviewed by a licensed physician and if approved you will get semaglutide drops right to your door prescribed legally by a doctor!

Mechanism of Action: The semaglutide drops are still semaglutide so they behave as a GLP-1 agonist. This agonism of the GLP-1 is a major player in what lowers appetite and hunger.

Benefits: Now semaglutide is notorious for the side effects that come with it. It is one of the most problematic GLP-1s in my opinion even though it is one of the weakest. The beauty of the drops is that you do not have to pin it, but more importantly you can essentially do a daily microdose and get your perfect dose out of it. Not to much to where you get sides, but not to little to where you feel nothing. I actually am a massive fan of these.

Side Effects: More expensive then other options

Dose: Determined by Doctor

How to Get These? Click Here

Semaglutide

Mechanism of Action: GLP-1 Agonist

Benefits: Decreased appetite, improved blood sugar, weight loss

Side Effects: 

• GI Distress
• Lethargy
• Nausea
• Bloating
• Muscle Loss

What Have I Seen In Real World?: Semaglutide is very very effective at lowering appetite in fact it is more effective then things like retatrutide, but the issue is that semaglutide comes with more side effects and in my opinion less weight loss then something like retat. This is though one of the best options for someone who really struggles with a huge appetite.

Dosing: – Beginner: (.25mg-.5mg) Intermediate: (.75mg-1.5mg) Advanced (2mg+) Everyone is different and will handle different dosing levels different. Once weekly**

Source: Click Here

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Tirzepatide

Mechanism of Action

• GLP-1 Agonist
• GIP Agonist

Benefits

• Increased Weight Loss Compared to Semaglutide (due to dual mechanism of action)
• Improved Blood Glucose Levels
• Improved Cardiac Health
• Lipid Management

Side Effects:

• GI Issues
• Lethargy
• Nausea
• Muscle Loss

What Have I Seen In Real World?: Tirzepatide like semaglutide is still a very powerful appetite suppressant. While it does not pack the same punch that does retat does it does do a very good job at lowering your appetite. I have also found that some people who do not do well with sema actually do pretty well with tirz. So it is stronger, and also some people have less side effects then with sema. Typically with GLP-1s as the mechanism of action gets more robust the side effects go down.

Dosing: Beginner (2-3mg) Intermediate: (5-10mg) Advanced: (10mg+ dose usually caps off at 15mg) once weekly

Source: Click Here

(code biohack)

Retatrutide

Mechanism of Action

• GLP-1
• GIP
• Glucagon Receptor

Benefits:

• Increased weight loss (arguably the most effective)
• Cleaner (less side effects) then Semaglutide
• Increased Metabolic Rate due to agonism of glucagon receptor
• Some people actually get an increase in energy from using this.

Side Effects:

• Similar Side effect profile to Tirz and Sema minus the energy issues
• Muscle Loss
• All in all it carries with it the typical GLP-1 side effects of things like GI issues, but it seems like the side effects are less pronounced despite it being the strongest
• Weaker Appetite Suppressant (could be good or bad thing)

What Have I Seen In Real World?: This is where things get interesting and the experience comes into play. Despite retat being the strongest it seems to be one of the cleanest options. What I mean by that is that it has a more minimal side effect profile then something like semaglutide. Now that I will say is that retat will help you to lose alot of weight, but the way in which it does it is through other pathways then just lowering your appetite. Sure it will definitely make you eat less, but it also will help to do things like raise your metabolic rate which will help you of course lose weight. This is where some people get confused as they think that because it is the strongest it is the most powerful appetite suppressor and also comes with the most side effects.

Dosing: Beginner (2mg), Intermediate (4-8mg) Advanced: (8mg+ hold at 12mg) once weekly

Source: Click Here

• (code biohack)

Mazdutide

Mechanism of Action:

• GLP-1 Receptor Agonist
• Glucagon Receptor Agonist

Benefits:

• Faster Weight Loss
• Improved Liver Health
• Increased Metabolic Rate
• Decreased Appetite
• Improved Blood Glucose Markers
• Lower Blood Pressure Levels
• Lower Blood Lipid Levels

Side Effects:

• Diarrhea
• Vomitting
• GI Distress
• Hypoglycmia

What Have I Seen In Real World?: From what I have seen when a compound agonizes the Glucagon receptor it seems to make the GLP-1 much more favorable. While I have limited experience working with people on Mazdutide simply because retatrutide is stronger, I have noticed that Mazdutide is fairly well tolerated by most people and is a decent option for weight loss. Side effects were also fairly minimal this this compound.

Dosing: Beginner (2-3mg) Intermediate (4-5mg) Advanced (6mg+) once weekly

Source: Click Here

(code: biohack)

Cagrisema

Mechanism of Action:

This product contains

• Semaglutide
• cagrilintide

Essentially these work together to form a synergistic bond to help produce even more optimal weight loss. I have noticed anecdotally this to be stronger then semaglutide and cagri (DUH), but it has a bit more side effects for me compared to taking the medications alone. If you are curious more on this you can just read the Semaglutide and Cagrilintide sections!

What Have I Seen In Real World?: To be honest I have noticed this is slightly stronger then sema, but for me it was pretty similar to be honest. I was  not a fan with how I was feeling when I was using this compound. It seems to me that I feel the best and my clients when the glucagon receptor is being agonized. In fact this compound was extremely disappointing for Nordisk in the clinical trials. This was designed to compete with tirzepatide and so far it is not.  Which you can read more about here

Dosing: Beginner ( .5mg-1mg ) Intermediate (1-2mg) Advanced (2mg+) once weekly

Source: Click Here

• Code (biohack)

Cagrilintide

Mechanism of Action:

• Binds to amylin receptors in brain making the user feel more full

Benefits:

• Decreased Appetite
• Improved Blood Glucose Levels
• Weight Loss

Side Effects:

• Weaker then Cagrisema when it came to change in HBA1c (semaglutide was not) according to this paper here
• Produced Less weight loss then cagrisema
• GI Distress
• Bloating
• Heart Burn
• Nausea

What Have I Seen In Real World?: To be fully honest cagrilintide is pretty weak by itself. Semaglutide and cagrisema are both stronger options then this one, and the weight loss is pretty mild. The side effects are not bad but with what we have this one is pretty meh.

Dosing: Beginner (.3mg-1mg) Intermediate (2-3mg) Advanced (4mg+) once weekly

Source: Click Here

(code: biohack)

Survodutide

Mechanism of Action:

• GLP-1 Receptor Agonist
• Glucagon Receptor Agonist

Benefits:

• Faster Weight Loss
• Increased Metabolic Rate
• Effective in Liver Disease
• Lower HBA1c levels

Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Constipation

What Have I Seen In Real World?:  Now this one I do think is interesting and atleast a bit promising. Really any compound that has the combined glucagon receptor agonism and the GLP-1 receptor agonism I get excited about as I think that is a very favorable combo. This one is in my eyes better then semaglutide and more effective but still weaker then retatrutide. It is fairly similar to mazdutide.

Dosing: Beginner (.6mg-1.5mg) Intermediate (2-4mg) Advanced (4+mg) once weekly

Source: Click Here

(code biohack)

Conclusion

To conclude we are in the era of the GLP-1 and with so many options it can be hard to choose which is best. Studies are great but sometimes real world experience can also help us greatly when it comes to selecting one that works best for us. Remember though no one has the same experience with each compound and everyone is different!